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Hippocampal volumetry: Normative data in the Indian population
Aravind Narayan Mohandas1, Rose Dawn Bharath1, Parthipulli Vasuki Prathyusha1
1Department of Neuro Imaging and Interventional Radiology, National Institute of Mental Health and Neuroscience, Banglore, Karnataka, India.
Annals of Indian Academy of Neurology
|September 16, 2014
Summary
This study establishes normative hippocampal volume (HV) data for the Indian population, revealing smaller volumes compared to Western data. These findings aid in diagnosing mesial temporal sclerosis (MTS) in Indian epilepsy patients.
Area of Science:
- Neurology
- Radiology
- Epilepsy Research
Background:
- Mesial temporal sclerosis (MTS) is the primary cause of temporal lobe epilepsy.
- Hippocampal volume (HV) quantification via MRI is crucial for MTS diagnosis and seizure control prognostication.
- Normative HV data is lacking for the Indian population, hindering accurate diagnosis.
Purpose of the Study:
- To establish normative hippocampal volume (HV) data specific to the Indian population.
- To facilitate more accurate diagnosis of mesial temporal sclerosis (MTS) in Indian patients.
Main Methods:
- Acquired MRI scans from 200 healthy Indian volunteers using a 3 Tesla scanner.
- Performed manual segmentation and volumetry using Siemens Syngo software.
- Analyzed data for associations with age, gender, and education; correlated with global data.
Main Results:
- Mean HV in the Indian cohort was 2.411 cm³ (SD -0.299), significantly smaller than Western populations.
- The right hippocampus was larger than the left (2.424 cm³ vs. 2.398 cm³).
- Higher HV was observed in males; no significant correlation with age or education.
Conclusions:
- The established normative HV data can serve as a standard for evaluating Indian epilepsy patients.
- This data is vital for improving the diagnostic accuracy of mesial temporal sclerosis in India.
