Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

2.0K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
2.0K
iPS Cell Differentiation01:22

iPS Cell Differentiation

2.2K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.2K
Stem Cell Culture01:17

Stem Cell Culture

4.5K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
4.5K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

4.5K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.5K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

22.8K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
22.8K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

3.7K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Normative data on the hind foot of Sprague-Dawley rats.

Laboratory animals·2026
Same author

The Underlying Mechanisms and Role of Negative Pressure Wound Therapy in Chronic Diabetic Wound Healing: A Systematic Review and Meta-Analysis.

International wound journal·2026
Same author

Electromagnetic exposure changes human Schwann cell motility and transcriptomic profile of hearing-loss-related genes.

iScience·2026
Same author

Self-Assembling Peptide Hydrogels Support Stromal Vascular Fraction Viability to Promote In Vivo Nerve Regeneration.

Advanced healthcare materials·2025
Same author

A conserved differentiation programme facilitates inhibitory neuron production in the developing mouse and human cerebellum.

Development (Cambridge, England)·2025
Same author

Golgi-mediated microtubule nucleation is associated with initiation of vertebrate peripheral neuron regeneration.

iScience·2025

Related Experiment Video

Updated: Apr 23, 2026

Dorsal Root Ganglia Neurons and Differentiated Adipose-derived Stem Cells: An In Vitro Co-culture Model to Study Peripheral Nerve Regeneration
09:17

Dorsal Root Ganglia Neurons and Differentiated Adipose-derived Stem Cells: An In Vitro Co-culture Model to Study Peripheral Nerve Regeneration

Published on: February 26, 2015

22.9K

Adipose derived stem cells and nerve regeneration.

Alessandro Faroni1, Richard Jp Smith1, Adam J Reid2

  • 1Blond McIndoe Laboratories, Institute of Inflammation and Repair, University of Manchester, Manchester, UK.

Neural Regeneration Research
|September 16, 2014
PubMed
Summary

Adipose-derived stem cells show promise for enhancing nerve regeneration in bioengineered grafts, offering a potential alternative to traditional nerve grafting methods for peripheral nerve injuries.

Keywords:
Schwann celladipose derived stem cellsaxonal regenerationbioengineered nerve graftcell therapynerve guidance tubesnerve repairperipheral nerve injury

More Related Videos

Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery
05:13

Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery

Published on: June 7, 2024

625
Differentiation Capacity of Human Aortic Perivascular Adipose Progenitor Cells
10:43

Differentiation Capacity of Human Aortic Perivascular Adipose Progenitor Cells

Published on: March 5, 2019

7.2K

Related Experiment Videos

Last Updated: Apr 23, 2026

Dorsal Root Ganglia Neurons and Differentiated Adipose-derived Stem Cells: An In Vitro Co-culture Model to Study Peripheral Nerve Regeneration
09:17

Dorsal Root Ganglia Neurons and Differentiated Adipose-derived Stem Cells: An In Vitro Co-culture Model to Study Peripheral Nerve Regeneration

Published on: February 26, 2015

22.9K
Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery
05:13

Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery

Published on: June 7, 2024

625
Differentiation Capacity of Human Aortic Perivascular Adipose Progenitor Cells
10:43

Differentiation Capacity of Human Aortic Perivascular Adipose Progenitor Cells

Published on: March 5, 2019

7.2K

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Neuroscience

Background:

  • Peripheral nerve injuries are prevalent, causing significant patient disability and societal costs.
  • Current treatments involve autografting, which sacrifices healthy nerves.
  • Bioengineered nerve grafts aim to overcome autograft limitations.

Purpose of the Study:

  • To review the potential of adipose-derived stem cells (ASCs) in improving nerve repair.
  • To explore the use of ASCs within bioengineered nerve grafts.

Main Methods:

  • Literature review of studies on peripheral nerve repair and stem cell therapy.
  • Analysis of ASC properties relevant to nerve regeneration.
  • Evaluation of bioengineered nerve graft strategies incorporating stem cells.

Main Results:

  • ASCs possess regenerative properties beneficial for nerve repair.
  • Incorporating ASCs into bioengineered grafts can enhance nerve regeneration.
  • This approach may reduce the need for autografts.

Conclusions:

  • Adipose-derived stem cells are a promising cell source for nerve tissue engineering.
  • Bioengineered nerve grafts combined with ASCs represent a viable strategy for peripheral nerve repair.
  • Further research is warranted to translate these findings into clinical practice.