Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of the Vascular System01:20

Overview of the Vascular System

2.7K
The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
2.7K
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

553
DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
553
Overview of Blood Vessels01:14

Overview of Blood Vessels

11.0K
The human cardiovascular system comprises five primary types of blood vessels: arteries, arterioles, veins, venules, and capillaries, each serving unique functions.
Arteries and Arterioles: Arteries are muscular and elastic vessels that primarily carry oxygenated blood from the heart to body tissues, except for the pulmonary artery, which carries deoxygenated blood. They have thick walls to withstand high pressure and contain a layer of muscle tissue, allowing them to expand or contract as...
11.0K
Development of Blood Vessels01:07

Development of Blood Vessels

2.0K
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
2.0K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.9K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In Vitro Models of Sturge-Weber Syndrome: Strengths, Limitations, and Future Goals.

International journal of molecular sciences·2026
Same author

Biomarker development in Sturge-Weber syndrome.

Journal of neurodevelopmental disorders·2025
Same author

Guidelines for the Diagnosis and Clinical Management of Cavernous Malformations of the Brain and Spinal Cord: Consensus Recommendations Based on a Systematic Literature Review by the Alliance to Cure Cavernous Malformation Clinical Advisory Board Experts Panel.

Neurosurgery·2025
Same author

Time to change our approach to presymptomatic treatment of Sturge-Weber syndrome.

Developmental medicine and child neurology·2024
Same author

Retrospective Analysis of Presymptomatic Treatment In Sturge-Weber Syndrome.

Annals of the Child Neurology Society·2024
Same author

Efficacy of cannabidiol in convulsive and nonconvulsive seizure types associated with treatment-resistant epilepsies in the Expanded Access Program.

Epilepsia·2023

Related Experiment Video

Updated: Apr 23, 2026

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
14:58

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations

Published on: October 20, 2017

9.0K

Brain Vascular Malformation Consortium: Overview, Progress and Future Directions.

Amy L Akers1, Karen L Ball2, Marianne Clancy3

  • 1Angioma Alliance, Norfolk, VA.

The Journal of Rare Disorders
|September 16, 2014
PubMed
Summary

The Brain Vascular Malformation Consortium (BVMC) fosters interdisciplinary research for rare brain vascular diseases like cerebral cavernous malformations, Sturge-Weber Syndrome, and hereditary hemorrhagic telangiectasia. This collaboration aims to develop biomarkers and treatments.

More Related Videos

Cerebrovascular Casting of the Adult Mouse for 3D Imaging and Morphological Analysis
06:42

Cerebrovascular Casting of the Adult Mouse for 3D Imaging and Morphological Analysis

Published on: November 30, 2011

25.5K
A Patient-Derived Xenograft Model for Venous Malformation
06:51

A Patient-Derived Xenograft Model for Venous Malformation

Published on: June 15, 2020

4.5K

Related Experiment Videos

Last Updated: Apr 23, 2026

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
14:58

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations

Published on: October 20, 2017

9.0K
Cerebrovascular Casting of the Adult Mouse for 3D Imaging and Morphological Analysis
06:42

Cerebrovascular Casting of the Adult Mouse for 3D Imaging and Morphological Analysis

Published on: November 30, 2011

25.5K
A Patient-Derived Xenograft Model for Venous Malformation
06:51

A Patient-Derived Xenograft Model for Venous Malformation

Published on: June 15, 2020

4.5K

Area of Science:

  • Neuroscience
  • Genetics
  • Rare Diseases

Background:

  • Brain vascular malformations present significant management challenges, including neurological morbidity and a lack of targeted therapies and biomarkers.
  • Historically, research in these rare diseases has been fragmented due to limited interdisciplinary communication.

Purpose of the Study:

  • To establish a collaborative framework for rare disease research through the Brain Vascular Malformation Consortium (BVMC).
  • To develop biomarkers for disease progression and severity in specific brain vascular malformations.
  • To create scalable databases for observational and longitudinal studies.

Main Methods:

  • The BVMC unites multidisciplinary, inter-institutional investigators focusing on familial Cerebral Cavernous Malformations type 1 (CCM1-CHM), Sturge-Weber Syndrome (SWS), and brain arteriovenous malformations in hereditary hemorrhagic telangiectasia (HHT).
  • Leveraging the Rare Disease Clinical Research Network (RDCRN) infrastructure, including central data management and Patient Support Organizations (PSOs).
  • Utilizing established clinical centers of excellence for enhanced patient recruitment.

Main Results:

  • The BVMC has established relational databases for observational and longitudinal studies.
  • Patient Support Organizations (Angioma Alliance, Sturge Weber Foundation, HHT Foundation International) have been integral to participant recruitment and support.
  • The consortium has enhanced patient recruitment for SWS and HHT studies.

Conclusions:

  • The BVMC provides valuable resources for the neurovascular community.
  • Future research will leverage combined BVMC and RDCRN resources to advance biomarkers and treatment strategies for brain vascular malformations.
  • Interdisciplinary collaboration is crucial for rare disease research advancement.