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Protection from vascular endothelial dysfunction in acute glycemic load-induced primary hypertension by vitamin C and

J X Xu1, L Su2, L Chen2

  • 1Department of Geratology, Fuzhou General Hospital, Fujian Medical University, Fuzhou, Fujian, China.

Genetics and Molecular Research : GMR
|September 16, 2014
PubMed

Insights

Acute high blood sugar impairs vascular endothelial function, particularly in hypertensive patients. However, high doses of antioxidant vitamins C and E can reverse this damage, showing a protective effect.

Area of Science:

  • Cardiovascular Research
  • Nutritional Science
  • Endocrinology

Background:

  • Hypertension is linked to impaired vascular endothelial function.
  • Acute glycemic load can negatively affect endothelial function.
  • Antioxidant vitamins may offer protection against endothelial dysfunction.

Purpose of the Study:

  • To investigate the impact of acute glycemic load on endothelial function in hypertensive patients.
  • To assess the protective effects of vitamins C and E against glycemic load-induced endothelial damage.

Main Methods:

  • Randomized controlled trial involving 39 hypertensive patients and 21 normal subjects.
  • Administration of oral glucose, glucose with vitamin C, or glucose with vitamins C and E.
  • Assessment of brachial artery flow-mediated vasodilation using Doppler ultrasound.
  • Measurement of serum antioxidant products over a 3-hour period.

Main Results:

  • Glycemic load significantly decreased endothelial function in hypertensive patients compared to normal subjects.
  • Vitamins C and E demonstrated a dose-dependent protective effect on endothelial function.
  • High doses of vitamins C and E reversed the acute endothelial damage caused by glycemic load.

Conclusions:

  • Acute hyperglycemia adversely affects vascular endothelial function, especially in individuals with hypertension.
  • Antioxidant vitamins C and E can mitigate the detrimental effects of glycemic load on endothelial function.
  • Therapeutic potential of high-dose antioxidant vitamins in managing hypertension-related vascular complications.

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