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Perforin expression in plaque psoriasis: an immunohistochemical study.
Rehab Monir Samaka1, Mohamed A Gaber, Nermin A Metwe
1Department of Pathology and.
Ultrastructural Pathology
|September 16, 2014
Summary
Psoriasis patients show increased perforin expression in skin lesions, correlating with disease severity. This suggests perforin may be a therapeutic target for plaque psoriasis.
Area of Science:
- Immunology
- Dermatology
- Cell Biology
Background:
- Psoriasis (PsO) is a T-cell-mediated immune disease.
- Perforin is a pore-forming protein found in cytotoxic T cells (CTLs) and natural killer (NK) cells.
Purpose of the Study:
- To evaluate immunohistochemical (IHC) expression of perforin in psoriatic skin.
- To correlate perforin expression with clinical and pathological variables in plaque psoriasis.
Main Methods:
- Prospective case-control study.
- 50 psoriasis patients and 30 healthy controls.
- Immunohistochemistry (IHC) for perforin in lesional and perilesional skin.
Main Results:
- Significantly higher perforin expression in lesional vs. perilesional psoriatic skin (p < 0.001).
- Perforin positivity correlated significantly with Psoriasis Area and Severity Index (PASI) (p < 0.000).
- Epidermal/dermal perforin localization associated with increased acanthosis and inflammation (p = 0.001).
Conclusions:
- Perforin expression is altered in plaque psoriasis.
- Perforin may play a role in early and late stages of psoriasis.
- Positive perforin expression indicates potential for targeted therapy in psoriasis.
