Neural functions of long noncoding RNAs in Drosophila

Long noncoding RNA (lncRNA) is an emerging category of transcript, and comprises the majority of the transcriptome of various complex organisms. The biological functions of only a handful of lncRNAs have been investigated in detail, showing involvement in a wide range of biological processes through different functional paradigms. However, most lncRNAs remain to be identified. Many lncRNAs are predicted to function, often preferentially, in the nervous system, potentially playing roles in mediating neural functions such as development, behavior, and cognition. To examine the biological significance and potential mechanisms of the remaining unknown neural lncRNAs, certain tractable model organisms, such as Drosophila, can provide advantages including the use of numerous genetic tools. Herein, we summarize recent progress on the in vivo or potential functions of Drosophila lncRNAs, in particular, behavior and development-related lncRNAs.