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Two-color flow cytometry analysis in alopecia areata.
1Department of Dermatology, Rheinische Friedrich-Wilhelms-Universität, Bonn, FRG.
Dermatologica
|January 1, 1989
Summary
Alopecia areata (AA) patients show reduced Leu 2a+8+ cells, a T cell subpopulation. This finding reveals new immune system abnormalities in alopecia areata, offering a potential diagnostic marker.
Area of Science:
- Immunology
- Dermatology
Background:
- Previous research indicates reduced T cytotoxic/suppressor cells and natural killer cells in alopecia areata (AA).
- Further investigation into mononuclear cell imbalances in AA is warranted.
Purpose of the Study:
- To identify additional circulating mononuclear cell abnormalities in patients with alopecia areata (AA).
- To investigate the Leu 2a+8+ T cell subpopulation in AA.
Main Methods:
- Blood samples from 35 AA patients and 44 controls were analyzed.
- Double labeling with monoclonal antibodies (anti-Leu 3a/8, Leu 2a/8, Leu 2a/15, Leu 7/15, Leu 7/11a) was employed.
Main Results:
- A statistically significant reduction in the Leu 2a+8+ T cell subpopulation was observed in AA patients (p < 0.008).
- This study identified further circulating mononuclear cell abnormalities in AA.
Conclusions:
- The reduced Leu 2a+8+ T cell subpopulation is a novel finding in alopecia areata.
- This subpopulation may serve as an additional diagnostic marker for AA.