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Mitral annular calcification and the serum osteocalcin level in patients with chronic kidney disease

Hilmi Umut Unal1, Murat Çelik, Yalçın Gökoğlan

  • 1Department of Nephrology and.

Renal Failure
|September 17, 2014
PubMed

Insights

In chronic kidney disease (CKD) patients, higher osteocalcin levels and mitral annular calcification (MAC) are linked to left ventricular diastolic dysfunction. Osteocalcin is an independent predictor of MAC in CKD.

Area of Science:

  • Nephrology
  • Cardiology
  • Biochemistry

Background:

  • Chronic kidney disease (CKD) is associated with cardiovascular complications.
  • Mitral annular calcification (MAC) is a marker of cardiovascular disease.
  • Inflammatory mediators and bone metabolism markers may play a role in CKD-related cardiovascular issues.

Purpose of the Study:

  • To investigate the relationship between inflammatory mediators, osteocalcin, and mitral annular calcification (MAC) in patients with chronic kidney disease (CKD).
  • To identify predictors of MAC in the CKD population.

Main Methods:

  • Retrospective evaluation of echocardiographic data from 60 CKD patients.
  • Division of patients into MAC-positive (MAC+) and MAC-negative (MAC-) groups.
  • Analysis of biochemical markers, including osteocalcin and high-sensitive C-reactive protein (hsCRP), in relation to MAC.

Main Results:

  • Patients with MAC (MAC+ group) exhibited significantly higher levels of hsCRP and osteocalcin compared to the MAC- group.
  • The mitral E/A ratio, mitral peak Ea velocity, hsCRP, and osteocalcin levels were strongly correlated with MAC.
  • Multivariate logistic regression identified osteocalcin level and mitral E/A ratio as independent predictors of MAC.

Conclusions:

  • CKD patients with MAC have elevated osteocalcin levels.
  • Left ventricular diastolic dysfunction is more prevalent in CKD patients with MAC.
  • Osteocalcin is a significant independent factor associated with MAC in CKD.
Abstract

Keywords:
Chronic kidney disease echocardiographymitral annular calcificationosteocalcin

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