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Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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[Severe childhood atopic dermatitis].

Anis Mahfoudh, Inès Zaraa, Thouraya Amara

    La Tunisie Medicale
    |September 17, 2014
    PubMed
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    Severe childhood atopic dermatitis (AD) is a rare but impactful skin condition. Effective treatment involves topical corticosteroids, antiseptics, emollients, and antihistamines, alongside family education for managing this chronic eczema.

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    Area of Science:

    • Dermatology
    • Pediatrics
    • Epidemiology

    Context:

    • Atopic dermatitis (AD) is a chronic, relapsing eczematous skin disease, often presenting in infants and children as part of atopic diathesis.
    • Severe childhood AD poses significant morbidity and can negatively impact quality of life.

    Purpose:

    • To characterize the epidemiological, clinical, treatment, and outcome features of severe childhood atopic dermatitis (AD) in a Tunisian hospital cohort.
    • To provide insights into the management and prognosis of severe pediatric AD.

    Summary:

    • A retrospective study analyzed 24 cases of severe childhood AD over 28 years (1981-2009).
    • The hospital incidence was 0.085‰, with a mean age of onset at 14 months and a male predominance (sex ratio 1.66).
    • Facial and generalized eczema, pruritus, and xerosis were common. Topical corticosteroids were the primary treatment, with infectious and ocular complications noted in 50% and 16.7% of cases, respectively. Recurrences were reported in 9 cases.

    Impact:

    • Severe childhood AD is rare in Tunisia, emphasizing the need for thorough understanding of therapeutic strategies by patients and families.
    • Highlights the chronic, relapsing, and pruritic nature of AD, requiring comprehensive management to mitigate morbidity and improve patient quality of life.