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Updated: Apr 23, 2026
Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
Published on: September 28, 2022
Significant role of macrophages in human cancers associated with Epstein-Barr virus (Review)
1Department of Pediatrics, National Hospital Organization, Wakayama National Hospital, Wakayama 644-0044, Japan.
Abstract:
Epstein-Barr virus (EBV) is a ubiquitous pathogen that was first identified as a human cancer virus. Many human cancers are associated with EBV, and we demonstrated that EBV infects macrophages. Macrophages infected with EBV show a close correlation with many human cancers, and thus more attention must be given to the role of macrophages infiltrating into cancer tissues associated with EBV. In this review, I discuss the role of macrophages in the process of EBV-associated oncogenesis with regard to interleukin-10.
Insights
Epstein-Barr virus (EBV) infects macrophages, which are linked to EBV-associated cancers. Further research into these infected macrophages is crucial for understanding cancer development.
Area of Science:
- Virology
- Immunology
- Oncology
Background:
- Epstein-Barr virus (EBV) is a known human cancer virus.
- EBV infection has been observed in macrophages.
- Macrophages infiltrating EBV-associated tumors warrant further investigation.
Purpose of the Study:
- To review the role of macrophages in EBV-associated oncogenesis.
- To highlight the significance of interleukin-10 in this process.
Main Methods:
- Literature review on EBV, macrophages, and cancer.
- Analysis of the interplay between EBV-infected macrophages and cancer development.
- Focus on the role of interleukin-10.
Main Results:
- EBV infects macrophages, a cell type frequently found in EBV-associated cancers.
- A correlation exists between EBV-infected macrophages and various human cancers.
- Interleukin-10 is implicated in the oncogenic process involving EBV and macrophages.
Conclusions:
- Macrophages play a significant role in EBV-associated oncogenesis.
- Targeting EBV-infected macrophages may offer therapeutic strategies for associated cancers.
- Understanding the function of interleukin-10 in this context is critical.
