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Computational modelling approaches to vaccinology

Francesco Pappalardo1, Darren Flower2, Giulia Russo1

  • 1Dipartimento di Scienze del Farmaco, University of Catania, Catania, Italy.

Pharmacological Research
|September 17, 2014
PubMed

Excepting the Peripheral and Central Nervous Systems, the Immune System is the most complex of somatic systems in higher animals. This complexity manifests itself at many levels from the molecular to that of the whole organism. Much insight into this confounding complexity can be gained through computational simulation. Such simulations range in application from epitope prediction through to the modelling of vaccination strategies. In this review, we evaluate selectively various key applications relevant to computational vaccinology: these include technique that operates at different scale that is, from molecular to organisms and even to population level.

Keywords:
Computational vaccinologyEpitopesImmune systemModellingSimulationsVaccine research

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