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Socioeconomic status and event free survival in pediatric acute lymphoblastic leukemia: a population-based cohort
Sumit Gupta1, Rinku Sutradhar2, Astrid Guttmann3
1Division of Haematology/Oncology, Department of Paediatrics and Program in Child Health Evaluative Sciences, The Hospital for Sick Children, 555 University Avenue, Toronto, Canada M5G 1X8.
Abstract:
The impact of socioeconomic status (SES) upon childhood cancer outcomes has not been extensively examined. Our objective was to determine the association between SES and event-free survival (EFS) among children with acute lymphoblastic leukemia (ALL) diagnosed in Ontario, Canada from 1995-2011 (N=1541) using Cox proportional hazards. Neither neighborhood-level median income quintile, distance from tertiary center, or rural residence significantly predicted EFS in the context of a universal healthcare system. Immigrant children experienced significantly superior EFS; confounding by ethnicity could not be ruled out. Confirmatory studies using additional individual-level SES variables are warranted.
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