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Copeptin levels are independent of ingested nutrient type after standardised meal administration--the CoMEAL study
Carla Walti1, Judith Siegenthaler, Mirjam Christ-Crain
1Division of Endocrinology, Diabetology, and Metabolism, University Hospital , Basel , Switzerland.
Context/Objective:
To clarify ambiguous published data, we determined whether standardized nutrient intake influences serum copeptin concentrations.
Materials/Methods:
Thirty healthy volunteers underwent oral glucose tolerance testing (OGTT) and mixed-meal tolerance testing (MMTT), respectively drinking 300 ml/237 ml of glucose-containing or fat/protein/carbohydrate-containing fluid. Copeptin was measured 30 min pre-("baseline")-180 min post-fluid intake.
Results:
Median [25th-75th percentile] copeptin fell from 4.9 [3.6-8.3]/4.9 [3.6-7.1] pmol/l at OGTT/MMTT baselines to 3.2 (2.8-5.9)/4.1 (2.7-6.1) pmol/l at post-OGTT/post-MMTT nadirs (150 min/120 min; p < 0.001, linear mixed-effect modeling).
Discussion/Conclusions:
Regardless of nutrient type ingested, copeptin did not increase, suggesting values can be interpreted independently of prandial status.
