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Endometriosis-associated infertility. Treatment options
1Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06510-8063.
The Journal of Reproductive Medicine
|February 1, 1989
Summary
Treating infertility in women with endometriosis is challenging. This review explores potential causes and discusses medical and surgical options like danocrine and GnRH agonists, favoring combined approaches.
Area of Science:
- Reproductive Medicine
- Gynecology
- Infertility Research
Background:
- Endometriosis is a complex gynecological condition often linked to infertility.
- The precise causal relationship between endometriosis and infertility remains unclear.
- Various molecular and cellular factors are implicated in endometriosis-associated infertility.
Purpose of the Study:
- To review the postulated molecular and cellular mechanisms underlying endometriosis-associated infertility.
- To discuss current medical and surgical treatment options for endometriosis-associated infertility.
- To identify the most effective treatment strategies.
Main Methods:
- Literature review of studies on endometriosis and infertility.
- Analysis of proposed molecular and cellular pathways.
- Evaluation of clinical outcomes for various treatment modalities.
Main Results:
- Several molecular and cellular mechanisms contribute to infertility in endometriosis patients.
- Medical treatments include danocrine, medroxyprogesterone acetate, and gonadotropin-releasing hormone agonists.
- Surgical interventions are also employed.
Conclusions:
- A definitive cause-and-effect link between endometriosis and infertility is not established.
- Combined medical and surgical treatments are often the preferred approach.
- Expectant management may be suitable in select cases.