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Correlation between plasma renalase level and coronary artery disease
Benhong He1, Jianjun Hao2, Weiwei Sheng3
1Benhong He, Department of Cardiovascular Medicine, Lichuan Hospital of Traditional Chinese Medicine, Hubei University of Chinese Medicine, Lichuan 445418, China.
Pakistan Journal of Medical Sciences
|September 17, 2014
Summary
Plasma renalase levels are lower in coronary artery disease (CAD) patients and correlate with stenosis severity. This suggests renalase may indicate CAD progression.
Area of Science:
- Cardiovascular Medicine
- Biochemistry
Background:
- Coronary artery disease (CAD) is a significant health concern.
- Understanding biomarkers for CAD progression is crucial.
Purpose of the Study:
- To investigate the relationship between plasma renalase levels and the severity of coronary artery stenosis in CAD patients.
Main Methods:
- Plasma renalase levels were measured using ELISA in 164 CAD patients and 140 healthy controls.
- Correlations were analyzed with the number of stenotic coronary artery branches and Syntax scores.
Main Results:
- CAD patients exhibited significantly lower plasma renalase levels compared to controls.
- Renalase levels decreased with increasing stenosis severity and were lower in higher-risk subgroups.
- Plasma renalase level was identified as a risk factor for CAD.
Conclusions:
- Plasma renalase levels are associated with CAD and reflect the degree of coronary artery stenosis.
- Plasma renalase may serve as a potential indicator for monitoring CAD progression.
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