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Published on: January 28, 2020
Correlation between plasma renalase level and coronary artery disease
Benhong He1, Jianjun Hao2, Weiwei Sheng3
1Benhong He, Department of Cardiovascular Medicine, Lichuan Hospital of Traditional Chinese Medicine, Hubei University of Chinese Medicine, Lichuan 445418, China.
Insights
Plasma renalase levels are lower in coronary artery disease (CAD) patients and correlate with stenosis severity. This suggests renalase may indicate CAD progression.
Area of Science:
- Cardiovascular Medicine
- Biochemistry
Background:
- Coronary artery disease (CAD) is a significant health concern.
- Understanding biomarkers for CAD progression is crucial.
Purpose of the Study:
- To investigate the relationship between plasma renalase levels and the severity of coronary artery stenosis in CAD patients.
Main Methods:
- Plasma renalase levels were measured using ELISA in 164 CAD patients and 140 healthy controls.
- Correlations were analyzed with the number of stenotic coronary artery branches and Syntax scores.
Main Results:
- CAD patients exhibited significantly lower plasma renalase levels compared to controls.
- Renalase levels decreased with increasing stenosis severity and were lower in higher-risk subgroups.
- Plasma renalase level was identified as a risk factor for CAD.
Conclusions:
- Plasma renalase levels are associated with CAD and reflect the degree of coronary artery stenosis.
- Plasma renalase may serve as a potential indicator for monitoring CAD progression.
Objective:
To explore the correlation between the plasma renalase level of coronary artery disease (CAD) patients and the degree of coronary artery stenosis.
Methods:
A total of 180 patients who received coronary angiography in our hospitals from August 2013 to October 2013 were selected as the CAD group, of which 164 were finally diagnosed as CAD. Another 140 healthy subjects were selected as the control group. The plasma renalase levels of the two groups were detected by ELISA to analyze CA-induced changes and to clarify the correlations with the number of branches with coronary artery stenosis and Syntax scores.
Results:
The plasma renalase level of the CAD group was significantly lower than that of the control group (P<0.05). The plasma renalase levels of the multi-branch and two-branch stenosis subgroups were significantly lower than that of the subgroup with normal coronary angiography outcomes (P<0.05), while the levels of the single-branch stenosis and normal subgroups were similar (P>0.05). Besides, the plasma renalase level of the low-risk subgroup was significantly higher than those of the medium-risk and high-risk subgroups (P<0.05), and the level of the medium-risk subgroup was significantly higher than that of the high-risk subgroup (P<0.05). Multivariate Logistic regression analysis showed that renalase level was the risk factor of CAD (OR=1.12, 95%CI: 1.03-3.34).
Conclusion:
Plasma renalase level was correlated with CAD, the changes of which may reflect the degree of coronary artery stenosis. Therefore, plasma renalase level can be used to indicate the progression of CAD.
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