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The effect of blood cell count on coronary flow in patients with coronary slow flow phenomenon
Korhan Soylu1, Okan Gulel2, Huriye Yucel3
1Korhan Soylu, MD, Assistant Professor, Department of Cardiology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
Insights
Blood cellular content, including elevated hematocrit, eosinophils, and basophils, is linked to coronary slow flow phenomenon (CSFP). These changes may impact coronary blood flow rates in patients with this condition.
Area of Science:
- Cardiology
- Hematology
- Vascular Biology
Background:
- The coronary slow flow phenomenon (CSFP) is a recognized coronary artery disease.
- The underlying pathological mechanisms of CSFP remain incompletely understood.
- Investigating blood cellular content offers a potential avenue to elucidate CSFP pathophysiology.
Purpose of the Study:
- To investigate the blood cellular content in patients diagnosed with CSFP.
- To determine the relationship between blood cellular composition and coronary flow rates in CSFP patients.
Main Methods:
- Analysis of selective coronary angiographies from 3368 patients to determine Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC).
- Comparison of demographic and laboratory findings between 78 CSFP patients and 61 controls with normal coronary flow.
- Assessment of hematocrit, hemoglobin, and specific white blood cell counts (eosinophils, basophils).
Main Results:
- CSFP patients exhibited significantly elevated mean corrected TFC (cTFC) values compared to controls.
- Elevated hematocrit, hemoglobin, eosinophil, and basophil counts were observed in CSFP patients.
- Increased hematocrit and eosinophil levels correlated significantly with higher TFC values.
Conclusions:
- Patients with CSFP show distinct alterations in blood cellular composition compared to those with normal coronary flow.
- Elevated hematocrit, eosinophil, and basophil counts are associated with CSFP.
- These hematological changes may play a role in modulating coronary blood flow rates.
Background And Objective:
The coronary slow flow phenomenon (CSFP) is a coronary artery disease with a benign course, but its pathological mechanisms are not yet fully understood.The purpose of this controlled study was to investigate the cellular content of blood in patients diagnosed with CSFP and the relationship of this with coronary flow rates.
Methods:
Selective coronary angiographies of 3368 patients were analyzed to assess Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC) values. Seventy eight of them had CSFP, and their demographic and laboratory findings were compared with 61 patients with normal coronary flow.
Results:
Patients' demographic characteristics were similar in both groups. Mean corrected TFC (cTFC) values were significantly elevated in CSFP patients (p<0.001). Furthermore, hematocrit and hemoglobin values, and eosinophil and basophil counts of the CSFP patients were significantly elevated compared to the values obtained in the control group (p=0.005, p=0.047, p=0.001 and p=0.002, respectively). The increase observed in hematocrit and eosinophil levels showed significant correlations with increased TFC values (r=0.288 and r=0.217, respectively).
Conclusion:
Significant changes have been observed in the cellular composition of blood in patients diagnosed with CSFP as compared to the patients with normal coronary blood flow. The increases in hematocrit levels and in the eosinophil and basophil counts may have direct or indirect effects on the rate of coronary blood flow.
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