Related Experiment Video

Updated: Apr 23, 2026

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

5.1K

MicroRNA regulation network in colorectal cancer metastasis

Jiao-Jiao Zhou1, Shu Zheng1, Li-Feng Sun1

  • 1Jiao-Jiao Zhou, Shu Zheng, Li-Feng Sun, Department of Surgical Oncology, the Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou 310009, Zhejiang Province, China.

World Journal of Biological Chemistry
|September 17, 2014
PubMed

Insights

MicroRNAs are key epigenetic regulators involved in colorectal cancer metastasis. Understanding microRNA networks offers new therapeutic and diagnostic targets for this widespread disease.

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Colorectal cancer (CRC) is a leading global cause of cancer death, with metastasis being the primary driver.
  • The intricate mechanisms underlying CRC metastasis are not fully understood.
  • MicroRNAs (miRNAs) are crucial epigenetic regulators impacting gene expression post-transcriptionally.

Purpose of the Study:

  • To explore the role of microRNAs in colorectal cancer metastasis.
  • To identify potential microRNA biomarkers for CRC metastasis.
  • To gain insights into therapeutic and diagnostic strategies for metastatic CRC.

Main Methods:

  • Analysis of the microRNAome in colorectal cancer.
  • Investigating the impact of miRNAs on epithelial-mesenchymal transition (EMT) and angiogenesis.
  • Correlating miRNA expression profiles with metastatic potential.

Main Results:

  • MicroRNAs play a significant role in key metastatic processes like EMT and angiogenesis in CRC.
  • Dissecting the microRNAome can identify specific miRNAs associated with CRC metastasis.
  • Evidence supports miRNAs' involvement in the biological pathways of CRC spread.

Conclusions:

  • MicroRNAs are critical players in colorectal cancer metastasis.
  • The microRNAome holds potential for identifying biomarkers for CRC metastasis.
  • Understanding miRNA networks offers novel therapeutic targets and diagnostic approaches for recurrent and metastatic CRC.
Keywords:
Colorectal neoplasmsMicroRNAsNeoplasm metastasis

More Related Videos

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts10:33

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts

Published on: April 29, 2014

10.3K
CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

2.5K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
20.8K
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.4K