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Related Experiment Videos

Fringe mode reflectance laser Doppler microscope system.

S Einav1, H J Berman, H C Dean

  • 1Faculty of Engineering, Tel Aviv University, Israel.

Journal of Biomedical Engineering
|January 1, 1989
PubMed
Summary
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A new reflectance fringe mode Laser Doppler microscope anemometer (LDMA) offers non-invasive, high-resolution velocity measurements in small blood vessels. This advanced LDMA technology improves accuracy and extends applications beyond traditional transmittance methods.

Area of Science:

  • Biomedical Engineering
  • Fluid Dynamics
  • Optical Measurement

Background:

  • Laser Doppler microscope anemometry (LDMA) is a valuable tool for velocity measurements.
  • Traditional transmittance mode LDMA has limitations in application sites, particularly for opaque tissues.

Purpose of the Study:

  • To design and test a novel reflectance fringe mode Laser Doppler microscope anemometer (LDMA).
  • To evaluate the performance and accuracy of the reflectance LDMA compared to transmittance mode.
  • To demonstrate the capability of reflectance LDMA for non-invasive velocity measurements in small blood vessels.

Main Methods:

  • Development of a novel beam splitter for adjustable laser beam control and aberration compensation.
  • Testing in a rectangular flow channel with water to validate velocity profiles.

Related Experiment Videos

  • Comparative velocity measurements in water, whole blood, and in vivo hamster cheek-pouch arterioles using both reflectance and transmittance LDMA modes.

    • Main Results:

    • Close agreement between predicted and measured velocity profiles in a flow channel.
    • Low deviations (<1.1% for water, <2.3% for blood, <2.8% for in vivo) between reflectance and transmittance modes.
    • Successful non-invasive velocity measurements in hamster arterioles (65-140 microns diameter) with high resolution (10 x 12 microns sensing volume).

    Conclusions:

    • Reflectance fringe mode LDMA provides accurate (better than 1.1%) and reproducible non-invasive velocity measurements.
    • This technology extends LDMA applicability to small blood vessels near surfaces of opaque organs and tissues.
    • Reflectance LDMA significantly broadens the scope of laser Doppler measurements in biological systems.