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Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Basophil activation tests: time for a reconsideration.

Astrid P Uyttebroek¹, Vito Sabato, Margaretha A Faber

¹Department of Immunology - Allergology - Rheumatology, Faculty of Medicine and Health Science, University of Antwerp, Antwerp University Hospital, CDE T.595, Universiteitsplein 1, 2610 Antwerpen, Belgium.

Expert Review of Clinical Immunology

|September 17, 2014

Summary

This summary is machine-generated.

The basophil activation test aids in diagnosing drug hypersensitivity and monitoring allergies. Further research is needed to improve its accessibility and reliability for broader allergy diagnostics.

Keywords:

CD63 allergy basophil activation test diagnosis drug hypersensitivity flow-cytometry food allergy hymenoptera venom

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Published on: May 31, 2021

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Area of Science:

Immunology
Allergy Diagnostics
Clinical Medicine

Background:

In vitro allergy diagnostics face challenges in identifying all allergens and cross-reactive structures.
Flow-assisted analysis of activated basophils has evolved as a diagnostic tool for hypersensitivity.
The utility of the basophil activation test (BAT) requires reassessment due to challenges with allergen extracts and assay accessibility.

Purpose of the Study:

To review the clinical applications of the basophil activation test.
To discuss the perspectives and challenges in flow-assisted allergy diagnosis.

Main Methods:

Review of existing literature on basophil activation test applications.
Analysis of diagnostic utility in various hypersensitivity conditions.

Main Results:

The basophil activation test is most valuable for diagnosing immediate drug hypersensitivity.
Preliminary results show potential in monitoring venom immunotherapy and food allergy follow-up.
Challenges remain in allergen extract preparation, characterization, and validation.

Conclusions:

The basophil activation test is a valuable tool for specific allergy diagnoses, particularly drug hypersensitivity.
Further development is needed to enhance accessibility and reliability for broader diagnostic applications.
Ongoing research is crucial for optimizing flow-assisted allergy diagnosis.