Related Experiment Video
Updated: Aug 14, 2026

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
Published on: July 30, 2016
A hypothesis of the pathogenesis of preeclampsia
1J. G. Strijdom Hospital, Department of Obstetrics and Gynaecology, University of the Witwatersrand, Auckland Park, South Africa.
Abstract:
The Atrial Natriuretic Factor discovered by De Bold in 1981, is currently being investigated by biochemists, physiologists and cardiologists. The physiological effects of this hormone closely resemble the normal changes occurring in pregnancy. Based on the experimental data published, the rise in the concentration of Atrial Natriuretic Factor in normal pregnancies may explain the physiological changes of pregnancy. It is postulated that the failure to induce a rise in the plasma concentration of Atrial Natriuretic Factor with its protective effects against the renin-angiotensin-aldosterone system will cause preeclampsia. A prospective study to compare serial Atrial Natriuretic Factor plasma concentrations with the pregnancy outcome from the point of view of preeclampsia is proposed to test this hypothesis.
Related Concept Videos
Hormonal Regulation
Teratogenicity
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Heart Failure II: Pathophysiology
Type II Diabetes II: Pathophysiology
Cerebral Edema ll: Pathophysiology

