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Striosomes and extrastriosomal matrix contain different amounts of immunoreactive choline acetyltransferase in the
E C Hirsch1, A M Graybiel, L B Hersh
1INSERM U289, Hôpital de la Salpêtrière, Paris, France.
Neuroscience Letters
|January 16, 1989
Abstract:
Cholinergic neuropil and cell bodies were identified in the human striatum by immunohistochemistry carried out with a polyclonal antibody raised against choline acetyltransferase (ChAT). The cholinergic neuropil was not uniformly distributed in the striatum, and especially in the caudate nucleus ChAT-poor zones corresponding to acetylcholinesterase (AChE)-poor striosomes were identified. Striosomal organization of ChAT-positive neuropil was also detected in striatal tissue from patients who had suffered parkinsonian and choreic disorders.