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Updated: Apr 23, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Notolutesins A-J, dolabrane-type diterpenoids from the Chinese liverwort Notoscyphus lutescens
Song Wang1, Rui-Juan Li, Rong-Xiu Zhu
1Department of Natural Products Chemistry, Key Laboratory of Chemical Biology of the Ministry of Education, School of Pharmaceutical Science, Shandong University , Jinan 250012, People's Republic of China.
Abstract:
Ten new dolabrane-type diterpenoids, notolutesins A-J (1-10), were isolated from the Chinese liverwort Notoscyphus lutescens, along with four known compounds. The structures of the new compounds were established on the basis of extensive spectroscopic data, and that of 1 was confirmed by single-crystal X-ray crystallography. The absolute configuration of 1 was determined by comparing its experimental and calculated electronic circular dichroism spectra. All of the isolates were evaluated for their cytotoxicity against a small panel of human cancer cell lines, and compound 1 exhibited an IC50 value of 6.2 μM against the PC3 human prostate cancer cell line.
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