Pyridynes and indolynes as building blocks for functionalized heterocycles and natural products
Adam E Goetz1, Tejas K Shah, Neil K Garg
1Department of Chemistry and Biochemistry, University of California, 607 Charles Young Drive East, Box 951569, Los Angeles, CA 90095, USA. neilgarg@chem.ucla.edu.
Abstract:
Heterocyclic arynes, or hetarynes, have been studied for over 100 years. However, challenges associated with observing these reactive species, as well as developing synthetically useful methods for their generation and trapping, have limited their use. This review provides a brief historical perspective on the field of hetarynes, in addition to a discussion of pyridyne and indolyne methodologies. Moreover, this review highlights the use of pyridynes, indolynes, and related strained intermediates in natural product synthesis.
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