Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet dysfunction in acute megakaryoblastic leukemia.

E M Pogliani1, M Colombi, E Cofrancesco

  • 1Istituto di Scienze Biomediche, Università di Milano, Italia.

Acta Haematologica
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Updated efficacy results from the JAVELIN Renal 101 trial: first-line avelumab plus axitinib versus sunitinib in patients with advanced renal cell carcinoma.

Annals of oncology : official journal of the European Society for Medical Oncology·2020
Same author

Clinical Variability in Two Macedonian Families with Arterial Tortuosity Syndrome.

Balkan journal of medical genetics : BJMG·2018
Same author

Spectrum of mucocutaneous, ocular and facial features and delineation of novel presentations in 62 classical Ehlers-Danlos syndrome patients.

Clinical genetics·2017
Same author

A recognizable systemic connective tissue disorder with polyvalvular heart dystrophy and dysmorphism associated with TAB2 mutations.

Clinical genetics·2017
Same author

Cost-Effectiveness Analysis of Induction Regimens Containing Anthracyclines in Adult Acute Myelogenous Leukemia.

Leukemia & lymphoma·2016
Same author

P-Glycoprotein Expression in Acute Myeloid Leukaemia Cells at Diagnosis: Its relationship to Daunorubicin or Idarubicin Induction Therapy and Survival.

Hematology (Amsterdam, Netherlands)·2016
Same journal

Progression-free survival effect sizes in randomized controlled trials of targeted cancer therapies with positive outcomes.

Acta haematologica·2026
Same journal

Dapagliflozin in Patients with homozygous β-Thalassemia and Albuminuria.

Acta haematologica·2026
Same journal

Efficacy of second-generation FLT3 inhibitors in FLT3-mutated AML: A meta-analysis of randomized controlled trials.

Acta haematologica·2026
Same journal

Limited prognostic value of ELN classification and relevance of molecular ontogeny in acute myeloid leukemia post myeloproliferative neoplasms: a retrospective multicenter study.

Acta haematologica·2026
Same journal

Real-World Data on First Relapse in Multiple Myeloma: Treatment Patterns and Outcomes in Finland Using Automated Data Collection.

Acta haematologica·2026
Same journal

Comparative efficacy of donor lymphocyte infusions in augmenting graft-versus-leukemia effect after allogeneic hematopoietic stem cell transplantation for patients with myeloid malignancies.

Acta haematologica·2026
See all related articles

Megakaryoblastic leukemia is linked to platelet dysfunction, causing abnormal bleeding. This thrombocytopathy may contribute to hemorrhagic diathesis in patients and requires consideration during treatment.

Area of Science:

  • Hematology
  • Oncology

Background:

  • Megakaryoblastic leukemia (MBL) is a rare and aggressive form of acute myeloid leukemia.
  • Patients with MBL often exhibit bleeding complications, but the underlying platelet abnormalities are not fully characterized.

Purpose of the Study:

  • To investigate the platelet function profiles in patients diagnosed with megakaryoblastic leukemia.
  • To determine if platelet dysfunction contributes to the hemorrhagic diathesis observed in these patients.

Main Methods:

  • Studied platelet function in 3 patients with MBL.
  • Assessed platelet counts, retention, bleeding time, and aggregation responses to various agonists (ADP, collagen, adrenaline, U46619).
  • Measured malondialdehyde, platelet serotonin, plasma beta-thromboglobulin, and platelet factor 4 (PF4).

Related Experiment Videos

Main Results:

  • All patients showed decreased platelet counts and abnormal platelet retention.
  • Defective platelet aggregation was observed in response to multiple agonists.
  • Reduced malondialdehyde and platelet serotonin levels were noted.
  • One patient had a prolonged bleeding time and markedly elevated PF4 levels.

Conclusions:

  • Megakaryoblastic leukemia is associated with a significant thrombocytopathy.
  • This platelet dysfunction may play a role in the hemorrhagic diathesis seen in MBL patients.
  • Platelet abnormalities persist even after clinical remission, impacting patient management.