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Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

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Published on: September 20, 2011

Polymer nanocarriers for dentin adhesion.

R Osorio¹, E Osorio², A L Medina-Castillo³

¹Dental School, University of Granada, Colegio Maximo, Campus de Cartuja s/n, 18017 Granada, Spain rosorio@ugr.es.

Journal of Dental Research

|September 18, 2014

Summary

This summary is machine-generated.

Zinc-loaded nanoparticles enhance dental adhesion by inhibiting collagen degradation and promoting mineral deposition. These nanoparticles offer a promising strategy for more durable dental restorations and improved dentin bonding.

Keywords:

adhesives dental hybrid layer nanopolymers remineralization zinc

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Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

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Published on: July 10, 2014

Area of Science:

Biomaterials Science
Dental Materials Science
Nanotechnology in Dentistry

Background:

Durable dental adhesion and protection of dentin collagen are critical for restoration longevity.
Matrix metalloproteinases (MMPs) degrade dentin collagen, compromising bond integrity.
Calcium- and phosphate-releasing agents are explored to enhance dentin bonding and remineralization.

Purpose of the Study:

To incorporate zinc-loaded polymeric nanocarriers into dental adhesive systems.
To inhibit MMP-mediated collagen degradation in dentin.
To facilitate calcium ion deposition at the resin-dentin interface.

Main Methods:

Zinc-loading of polymeric nanoparticles (nanoMyP) via ZnCl2 immersion.
Bioactivity testing using simulated body fluid (Kokubo test).
Analysis of zinc-loading, mineral deposition, and bond strength using electron microscopy and mechanical testing.
Assessment of MMP-mediated collagen degradation via ICTP concentration measurement.

Main Results:

Nanoparticles were successfully zinc-loaded and exhibited a chelating effect, retaining calcium.
Nanoparticles did not infiltrate intertubular dentin but remained on the hybrid layer, without affecting bond strength.
Calcium and phosphorus deposition was observed on nanoparticles at the hybrid layer.
Nanoparticle application reduced MMP-mediated collagen degradation in dentin.

Conclusions:

Zinc-loaded nanoparticles can be integrated into dental adhesive systems.
These nanoparticles inhibit dentin MMP collagen degradation.
They create an environment conducive to mineral growth at the bonded interface, potentially improving restoration durability.