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[Keep an eye on the side effects].

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¹Hautklinik, Universitätsklinikum Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Deutschland.

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Summary

This summary is machine-generated.

Long-term minocycline use can cause grey-black skin, sclera, and teeth pigmentation. Early recognition and patient counseling are crucial for managing this cosmetically disturbing side effect.

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Area of Science:

Dermatology
Pharmacology

Background:

Minocycline is an antibiotic commonly used for various infections.
Drug-induced hyperpigmentation is a known but often overlooked side effect.

Observation:

A 52-year-old male presented with progressive grey-black pigmentation affecting facial skin, sclera, and teeth.
The condition was linked to prolonged minocycline ingestion, confirmed by patient history and skin biopsy.

Findings:

Minocycline-induced hyperpigmentation presents in four distinct patterns, varying in clinical appearance and microscopic characteristics.
Hyperpigmentation can emerge within weeks of starting minocycline therapy.

Implications:

Clinicians must be vigilant for early signs of minocycline-induced hyperpigmentation.
Informing patients about this persistent and cosmetically concerning side effect is essential for management and adherence.