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Maternal and perinatal predictors of newborn iron status
Susan B Morton, Rajneeta Saraf, Dinusha K Bandara
1Growing Up in New Zealand, Centre for Longitudinal Research - He Ara ki Mua, University of Auckland, 261 Morrin Road, Glen Innes, PO Box 18288, Auckland 1743, New Zealand. cc.grant@auckland.ac.nz.
Insights
Seven percent of newborns in New Zealand show iron deficiency at birth. Maternal milk consumption during pregnancy was linked to lower infant serum ferritin levels.
Area of Science:
- Neonatal Health
- Nutritional Biochemistry
Background:
- Iron deficiency at birth can impact infant development and long-term health outcomes.
- Understanding iron status in newborns is crucial for public health initiatives.
Purpose of the Study:
- To determine the prevalence of iron deficiency in a New Zealand infant population at birth.
- To investigate associations between cord blood iron status markers and maternal/birth characteristics.
Main Methods:
- Cord blood samples were collected from 131 infants in the Growing Up in New Zealand cohort study.
- Serum ferritin (SF) and haemoglobin (Hb) concentrations were measured.
- Statistical analyses explored relationships between SF/Hb and maternal/birth factors.
Main Results:
- Seven percent of newborns exhibited low cord serum ferritin (SF <35 mcg/L), indicating iron deficiency.
- Two newborns were anaemic (Hb <130 g/L); none had iron deficiency anaemia.
- Higher maternal milk intake (≥3 servings/day) was associated with lower median SF levels in newborns (131 vs. 151 mcg/L, P=0.04).
Conclusions:
- Iron deficiency is a notable concern in 7% of New Zealand newborns.
- Maternal milk consumption during pregnancy may be inversely associated with newborn iron stores.
Aim:
To describe iron status at birth in a population sample of children.
Method:
Cord blood samples were obtained at birth from 131 infants enrolled in the cohort study Growing Up in New Zealand. Cord blood serum ferritin (SF) and haemoglobin (Hb) concentrations were measured and associations of SF and Hb with maternal and birth characteristics were determined.
Results:
Demographics were comparable to the larger cohort, except for having a higher pre-pregnancy body mass index (26.9 vs. 25.4 kg/m2, P=0.005), lower frequency of cigarette smoking during pregnancy (2% vs. 11%, P=0.0004), and smaller proportion with birth-weight <2500 g (0% vs. 5%, P=0.03). Median (interquartile range) SF was 135 (88-180) mcg/L and mean (plus or minus SD) Hb was 160 plus or minus 17 g/L. Eight newborns (7%) had cord SF levels indicative of iron deficiency (SF <35 mcg/L), two newborns were anaemic (Hb <130 g/L) and none had iron deficiency anaemia. Median SF was lower in newborns whose mothers consumed greater than or equal to 3 servings of milk/day during the pregnancy (131 vs. 151 mcg/L, P=0.04). No other associations with SF or Hb were observed.
Conclusion:
Iron deficiency is present in 7% of newborns in New Zealand. Newborns whose mothers consumed more milk during pregnancy had a lower median SF concentration.
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