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Longitudinal growth and post-discharge mortality and morbidity among extremely low birth weight neonates
Kanya Mukhopadhyay1, Deepak Louis, Gagan Mahajan
1Neonatal Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India Correspondence to: Dr Kanya Mukhopadhyay, Additional Professor (Neonatology), Department of Pediatrics, PGIMER, Chandigarh 160 012, India. kanyapgi@gmail.com.
Insights
Extremely low birth weight (ELBW) neonates show significant growth deficits by 2 years corrected age. Despite improvements, many remain malnourished, with notable mortality and re-admission rates in the first year.
Area of Science:
- Neonatalogy
- Pediatric Growth and Development
- Public Health
Background:
- Extremely low birth weight (ELBW) neonates face long-term health challenges.
- Post-discharge outcomes for ELBW infants require ongoing monitoring.
Purpose of the Study:
- To assess the growth, mortality, and morbidity of ELBW neonates up to 2 years corrected age.
- To identify persistent growth abnormalities in this vulnerable population.
Main Methods:
- Longitudinal tracking of weight, length, and head circumference using WHO growth charts.
- Calculation of malnutrition indicators including underweight, stunting, microcephaly, and wasting.
- Follow-up at corrected ages 3, 6, 9, 12, and 24 months.
Main Results:
- Significant improvements in Z-scores for weight, length, and head circumference were observed between 3 and 24 months.
- A substantial percentage of ELBW infants remained malnourished at 2 years corrected age.
- Mortality was 11% and re-admission rates reached 44% within the first year.
Conclusions:
- ELBW neonates exhibit persistent significant growth retardation at 2 years corrected age.
- Close monitoring and intervention are crucial for managing long-term outcomes in ELBW survivors.
Objective:
To study post-discharge growth, mortality and morbidity of extremely low birth weight neonates at corrected age of 2 years.
Methods:
Weight, length and head circumference were compared on WHO growth charts at corrected ages 3 (n=54), 6, 9, 12 (n=51) and 24 months (n=37); rates of underweight, stunting, microcephaly and wasting were calculated.
Results:
The mean Z-score for weight, length, head circumference and weight-for-length significantly improved from 3 to 24 months (P<0.001); a significant proportion remained malnourished at 2 years. Nine infants (11%) died and 35 (44%) required re-admission during first year of age.
Conclusions:
Extremely low birth weight neonates remain significantly growth retarded at corrected age of 2 years.
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