Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Apr 23, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

17.6K

Assisted reproductive technology in SLE and APS.

A B Levine1, M D Lockshin2

  • 1Hospital for Special Surgery, New York, USA levinea@hss.edu.

Lupus
|September 18, 2014
PubMed
Summary

Assisted reproductive technology (ART), including in vitro fertilization (IVF), is safe for patients with systemic lupus erythematosus and antiphospholipid syndrome. These procedures do not worsen disease activity or increase thrombosis risk.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Longitudinal evaluation of diffusion tensor imaging and cognition in systemic lupus erythematosus.

Lupus·2018
Same author

Feasibility of Patient-Reported Outcomes Measurement Information System (PROMIS®) computerized adaptive tests in systemic lupus erythematosus outpatients.

Lupus·2018
Same author

Functional Magnetic Resonance Imaging of Working Memory and Executive Dysfunction in Systemic Lupus Erythematosus and Antiphospholipid Antibody-Positive Patients.

Arthritis care & research·2016
Same author

The efficacy and safety of bazedoxifene in postmenopausal women by baseline kidney function status.

Climacteric : the journal of the International Menopause Society·2013
Same author

Site differences in mild cognitive dysfunction (MCD) among patients with systemic lupus erythematosus (SLE).

Lupus·2012
Same author

Antiphospholipid: to test, or not to test, that is the question.

International journal of clinical practice·2012

Area of Science:

  • Reproductive Medicine
  • Rheumatology
  • Immunology

Background:

  • Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are autoimmune conditions.
  • Patients with SLE and APS may require assisted reproductive technology (ART).

Purpose of the Study:

  • To evaluate the safety and efficacy of ART, including in vitro fertilization (IVF), in patients with SLE and APS.
  • To determine if antiphospholipid antibodies (aPL) impact IVF outcomes.

Main Methods:

  • Review of ART procedures in patients with SLE and APS.
  • Analysis of disease flare and thrombosis risk post-ART.
  • Correlation of aPL presence with IVF pregnancy outcomes.

Main Results:

Keywords:
Antiphospholipid syndromeanticardiolipin antibodieslupus anticoagulantpregnancysystemic lupus erythematosus

More Related Videos

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

2.6K
Murine Bilateral Renal Lymphadenectomy
06:20

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

208

Related Experiment Videos

Last Updated: Apr 23, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

17.6K
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

2.6K
Murine Bilateral Renal Lymphadenectomy
06:20

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

208
  • ART procedures, including IVF, did not increase the risk of disease flare or thrombosis in patients with SLE and APS.
  • The presence of antiphospholipid antibodies (aPL) did not independently predict IVF pregnancy outcomes.
  • Quiescent disease for at least 6 months prior to ART is recommended for optimal outcomes.

    • Conclusions:

    • ART, including IVF, can be safely considered for patients with SLE and APS.
    • Disease activity and thrombosis risk are not significantly elevated by ART in this population.
    • Optimizing disease control before ART is crucial for successful pregnancy in patients with SLE and APS.