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Using the GRADE system in diagnostic strategy: the case of antiphospholipid syndrome
M Mendes de Abreu1, R A Levy2, D Wahl3
1Universidade Federal de São Carlos, Sao Carlos, Brazil mirhelen@terra.com.br.
Abstract:
Diagnostic strategy studies commonly focus on the accuracy of tests in diagnosing, and grading this body of evidence is a challenge in itself because (1) standard tools for grading evidence were designed for questions about treatment rather than diagnostic testing; and (2) the clinical usefulness of a diagnostic strategy depends on multiple links in a chain of evidence connecting the performance of a test to changes in clinical outcomes. The application of the GRADE approach requires a shift in clinicians' thinking to clearly recognize that, whatever their accuracy, diagnostic tests are valuable only if they result in improved outcomes for patients.
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