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Updated: Apr 23, 2026

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
Published on: February 14, 2022
Long term negative pressure ventilation: Rescue for the failing fontan?
Shriprasad R Deshpande1, Kevin O Maher1
1Shriprasad R Deshpande, Kevin O Maher, Division of Pediatric Cardiology, Emory University, Children's Healthcare of Atlanta, Atlanta, GA 30322, United States.
Abstract:
Current treatment strategies for single ventricle patients include non-intervention strategy, surgical palliation or primary transplantation. Surgical palliation includes a staged operative course culminating in the Fontan operation. With progress in surgical techniques, the survival has been improving. However, almost all of these Fontan patients will demonstrate pathophysiologic changes that ultimately constitute "Fontan failure physiology". This article reviews the pathophysiologic changes, current approach to management of these patients and proposes a novel way of reversing some of the pathophysiologic changes by utilization of negative pressure ventilation.
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