[GnRH agonist/hMG stimulation in gamete intrafallopian transfer (GIFT)]

Area of Science:

• Reproductive Medicine
• Infertility Treatment
• Assisted Reproductive Technologies

Background:

• Gamete intra-Fallopian transfer (GIFT) is an assisted reproductive technology.
• Ovarian stimulation protocols are crucial for successful GIFT procedures.
• Preventing premature luteinization is key for optimal oocyte retrieval.

Purpose of the Study:

• To evaluate the efficacy of a combined gonadotropin-releasing hormone antagonist (GnRH-A)/human menopausal gonadotropin (hMG) stimulation protocol for GIFT.
• To assess pregnancy rates and influencing factors in couples undergoing GIFT.
• To compare different administration forms of GnRH-A.

Main Methods:

• A total of 61 couples underwent GIFT over 17 months.
• Sixty-nine stimulation cycles utilized a combination of GnRH-A and hMG.
• Two GnRH-A administration methods were used: daily intranasal spray and monthly depot injection.

Main Results:

• A clinical pregnancy rate of 32% (22 pregnancies) was achieved per stimulation cycle.
• Pregnancy rates varied by infertility cause, with cervical infertility at 58% and male factors at 15%.
• Higher pregnancy rates correlated with the number and maturity of transferred oocytes.

Conclusions:

• The combined GnRH-A/hMG stimulation therapy enables prolonged follicular development without premature luteinization.
• This protocol offers a flexible and effective strategy for ovarian stimulation, increasing follicle and oocyte yield for GIFT.
• The study demonstrates the successful application of this protocol in achieving pregnancies via GIFT.