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Updated: Apr 23, 2026
Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
Published on: May 30, 2011
The effect of the section thickness used for 2- and 3-dimensional quantification of dual-energy perfusion computed
Takafumi Nomura1, Munemasa Okada, Yoshiteru Nakashima
1From the *Department of Radiology, Yamaguchi University Graduate School of Medicine; †Department of Radiology, Yamaguchi Grand Medical Center; ‡Department of Radiology, Yamaguchi University Hospital; and §Computer-aided Diagnosis and Biomedical Imaging Research Biomedical Engineering, Applied Medical Engineering Science Graduate School of Medicine, Yamaguchi University, Yamaguchi, Japan.
Purpose:
To retrospectively investigate the effect of the section thickness used for quantifying dual-energy perfusion computed tomography (DEpCT) during 2- and 3-dimensional evaluation.
Methods:
Sixty-six patients (22 males and 44 females; mean age, 59.3 years) suspected of having an acute pulmonary embolism underwent DEpCT, and 15patients were diagnosed to have intrapulmonary clots (IPCs). Two-dimensional DEpCT images were reconstructed into various section thicknesses from 1 to 10 mm at the main pulmonary artery, and the ratios of the low attenuation area (LAA) ranging from 1 to 5 HU (%LAA5) and 10 HU (%LAA10) on DEpCT were compared with the relative areas of the lung with attenuation coefficients lower than -950 HU (RA-950) using the lung CT images of each section thickness. Three-dimensional values of DEpCT were reconstructed with 3 different section thicknesses (1, 3, and 10 mm) and were analyzed for the presence of IPC burden using the factors suggesting IPC burden, including the right/left ventricular diameter ratio and CT obstruction index.
Results:
The mean attenuation and image noise were decreased as the section thickness increased. In the 2-dimensional analysis, the %LAA5 and %LAA10 had the smallest value at 1-mm section, and DEpCT with thinner sections had a correlation with the RA-950 (r = 0.22-0.23, P < 0.05). The 3-dimensional values of DEpCT reconstructed with a 1- or 3-mm section thickness had a correlation with the CT obstruction index (r = 0.52-0.59, P < 0.05) and right/left ventricular diameter ratio (r = 0.60-0.68, P < 0.01).
Conclusions:
The thinner images should be used for 2- and 3-dimensional quantification of DEpCT.
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