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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
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Burnt sugarcane harvesting is associated with acute renal dysfunction
Ubiratan Paula Santos1, Dirce Maria T Zanetta2, Mário Terra-Filho1
1Pulmonary Division, Heart Institute, University of São Paulo Medical School, São Paulo, Brazil.
Kidney International
|September 18, 2014
Summary
Burnt sugarcane harvesting acutely impairs kidney function in healthy workers. This occupational hazard is linked to dehydration, inflammation, oxidative stress, and rhabdomyolysis, contributing to kidney injury.
Area of Science:
- Nephrology
- Occupational Health
- Environmental Medicine
Background:
- A chronic kidney disease epidemic affects sugarcane workers in Central America.
- Acute kidney dysfunction episodes are a potential contributing factor.
Purpose of the Study:
- To investigate the acute renal effects of burnt sugarcane harvesting on healthy workers.
Main Methods:
- Assessed renal function, creatine phosphokinase, oxidative stress markers, and inflammatory markers.
- Collected blood and urine samples before and after harvesting workdays.
Main Results:
- Estimated glomerular filtration rate decreased by ~20% post-shift.
- 18.5% of workers showed acute kidney injury markers.
- Changes correlated with dehydration, inflammation, oxidative stress, and rhabdomyolysis.
Conclusions:
- Burnt sugarcane harvesting induces acute renal dysfunction in healthy individuals.
- Occupational exposure involves dehydration, systemic inflammation, oxidative stress, and rhabdomyolysis.
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