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Association of Aortic Valve Sclerosis with Previous Coronary Artery Disease and Risk Factors

Filipe Carvalho Marmelo1, Sónia Matilde Fonseca Mateus1, Alexandre José Marques Pereira1

  • 1Escola Superior de Saúde Dr. Lopes Dias, Portugal.

Arquivos Brasileiros De Cardiologia
|September 18, 2014
PubMed

Insights

Aortic valve sclerosis (AVS) is linked to a higher prevalence of coronary artery disease and common risk factors like hypertension and diabetes. This study confirms an association between AVS and cardiovascular issues.

Area of Science:

  • Cardiology
  • Echocardiography
  • Valvular Heart Disease

Background:

  • Aortic valve sclerosis (AVS) involves thickening, calcification, and stiffening of aortic leaflets without commissure fusion.
  • Existing research suggests a correlation between AVS and coronary artery disease (CAD).

Purpose of the Study:

  • To examine the association between aortic valve sclerosis (AVS) and prior coronary artery disease.
  • To investigate the relationship between AVS and classical cardiovascular risk factors.

Main Methods:

  • Analysis of transthoracic echocardiography data from 2,493 individuals (mean age 67.5 years, 50.7% female).
  • Data collected between August 2011 and December 2012.

Main Results:

  • Aortic valve sclerosis (AVS) was identified in 36.7% of individuals.
  • Significant associations were found between AVS and hypertension (p < 0.001), myocardial infarction (p = 0.007), diabetes (p = 0.006), and impaired left ventricular systolic function (p < 0.001).

Conclusions:

  • Individuals with AVS exhibit increased rates of hypertension, stroke, hypercholesterolemia, myocardial infarction, diabetes, and reduced left ventricular systolic function compared to those without AVS.
  • The study confirms an association between aortic valve sclerosis and previous coronary artery disease and its risk factors.

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