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Related Experiment Video

Updated: Apr 23, 2026

Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse

Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse

Published on: March 8, 2013

"Stocking effect" in lymphoscintigraphy.

Georgia Keramida¹, Melissa Humphrys, Nicola Ryan

¹Department of Nuclear Medicine, Royal Sussex County Hospital , Brighton, United Kingdom .

Lymphatic Research and Biology

|September 18, 2014

Summary

This summary is machine-generated.

Lymphoscintigraphy can diagnose lymphedema, but compression stockings can obscure dermal backflow. Removing stockings before imaging is crucial for accurate diagnosis and understanding lymphatic dysfunction.

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Area of Science:

Nuclear medicine
Vascular imaging
Lymphatic system diagnostics

Background:

Lymphoscintigraphy using technetium-99m-nanocolloid is a standard diagnostic tool for evaluating limb swelling and confirming lymphedema.
Dermal backflow, a key indicator of lymphatic dysfunction, is identified as lymph diverting into superficial skin lymphatics.

Observation:

A case study highlights how a compression stocking partially obscured the dermal backflow sign during lymphoscintigraphy.
The case also revealed lymphatic dysfunction in the asymptomatic contralateral limb, a common yet underrecognized finding.

Findings:

Compression stockings can interfere with the accurate visualization of dermal backflow, a critical diagnostic marker in lymphoscintigraphy.
Lymphatic dysfunction is frequently present in the clinically normal limb of patients with unilateral swelling, suggesting a systemic component.

Implications:

Compression stockings should be removed prior to radiotracer injection and imaging in lymphoscintigraphy to ensure accurate detection of dermal backflow.
The findings underscore the importance of considering contralateral limb involvement and the principles of compression therapy in managing lymphedema.