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Histological modification in TRAM flap in rats treated with pentoxifylline
Audrien Furlan de Lucca1, Adriano Guimarães Brasolin1, Roney Gonçalves Fechine Feitosa1
1Surgery Department, UNIFESP.
Acta Cirurgica Brasileira
|September 18, 2014
Summary
Pentoxifylline significantly reduced TRAM flap necrosis in rats by increasing blood vessel concentration in ischemic tissue. This study highlights pentoxifylline
Area of Science:
- Plastic Surgery
- Vascular Biology
- Pharmacology
Background:
- TRAM flap surgery is crucial for reconstruction but susceptible to necrosis.
- Improving blood supply to ischemic flaps is vital for surgical success.
Purpose of the Study:
- To evaluate the effect of pentoxifylline on blood vessel concentration in a rat TRAM flap model.
- To assess pentoxifylline's efficacy in reducing TRAM flap necrosis.
Main Methods:
- A rat model of caudal unipedicle TRAM flap was utilized.
- Rats received either saline (control) or pentoxifylline (20mg/kg/day) for seven days pre-surgery.
- Flap necrosis and capillary density in zone IV were assessed on postoperative day five.
Main Results:
- Pentoxifylline treatment reduced flap necrosis from 58.7% to 31.1% (p=0.003).
- Capillary vessel number in ischemic zone IV significantly increased in the pentoxifylline group (71.9 vs 33.4, p=0.008).
Conclusions:
- Pentoxifylline effectively reduces necrosis in TRAM flaps.
- Pentoxifylline enhances neovascularization in ischemic flap zones.
