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Grading uterine endometrioid carcinoma: a proposal that binary is best

Niamh Conlon1, Mario M Leitao, Nadeem R Abu-Rustum

  • 1Departments of *Pathology †Surgery, Gynecology Service, Memorial Sloan Kettering Cancer Center ‡Weill Cornell Medical College, New York, NY.

The American Journal of Surgical Pathology
|September 18, 2014
PubMed
Summary

No abstract available in PubMed .

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The uterine wall consists of three histological layers: the perimetrium, myometrium, and endometrium. The outermost perimetrium is a thin, serous membrane connected with the broad ligament on the sides, which helps anchor the uterus in the pelvic cavity. The thickest layer, myometrium, is mainly made up of smooth muscle tissue bundles. Its contractions are vital in facilitating the expulsion of the uterine lining, fetus, and placenta during menstruation and childbirth.
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DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...
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