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Updated: Apr 23, 2026

Generation of Self-assembled Vascularized Human Skin Equivalents
Published on: February 12, 2021
Collagen peptide and vitamin C additively attenuate age-related skin atrophy in Sod1-deficient mice
Shuichi Shibuya1, Yusuke Ozawa, Toshihiko Toda
1a Department of Advanced Aging Medicine , Chiba University Graduate School of Medicine , Chiba , Japan.
Abstract:
Age-related skin thinning is correlated with a decrease in the content of collagen in the skin. Accumulating evidence suggests that collagen peptide (CP) and vitamin C (VC) transcriptionally upregulate type I collagen in vivo. However, the additive effects of CP and VC on age-related skin changes remain unclear. We herein demonstrate that CP and a VC derivative additively corrected age-related skin thinning via reduced oxidative damage in superoxide dismutase 1 (Sod1)-deficient mice. Co-treatment with these compounds significantly normalized the altered gene expression of Col1a1, Has2, and Ci1, a proton-coupled oligopeptide transporter, in Sod1(-/-) skin. The in vitro analyses further revealed that collagen oligopeptide, a digestive product of ingested CP, significantly promoted the bioactivity of the VC derivative with respect to the migration and proliferation of Sod1(-/-) fibroblasts. These findings suggest that combined treatment with CP and VC is effective in cases of age-related skin pathology.
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