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Updated: Apr 23, 2026
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An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
Published on: November 28, 2010
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Antigen-specific active immunotherapy for ovarian cancer
Ninke Leffers1, Toos Daemen, Wijnand Helfrich
1Obstetrics & Gynecology CB30, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P.O. Box 30.001, Groningen, Netherlands, 9700 RB.
The Cochrane Database of Systematic Reviews
|September 18, 2014
Summary
Antigen-specific active immunotherapy shows promising immunological responses in ovarian cancer but lacks clinical efficacy. Further large, well-designed trials are needed to assess its true potential and safety.
Area of Science:
- Oncology
- Immunotherapy
- Clinical Trials
Background:
- Ovarian cancer prognosis remains poor despite chemotherapy advancements.
- Antigen-specific active immunotherapy offers a potential alternative treatment by stimulating anti-tumour immune responses.
Purpose of the Study:
- To evaluate the feasibility of antigen-specific active immunotherapy for ovarian cancer.
- Primary outcomes include clinical efficacy and antigen-specific immunogenicity.
Main Methods:
- Systematic review of randomized controlled trials (RCTs) and non-randomized studies.
- Searches conducted across multiple databases up to October 2013.
- Data extraction and risk of bias assessment performed independently by two reviewers.
Main Results:
- Fifty-five studies involving 3051 women were included.
- CA-125 targeted antibody therapy showed no clinical benefit in large RCTs despite immune response induction.
- Other antigen-specific therapies showed promising immunological results but require further RCT evaluation.
Conclusions:
- Currently, no clinically effective antigen-specific active immunotherapy is available for ovarian cancer.
- Results must be interpreted cautiously due to significant limitations in assessing risk of bias.
- Further research in well-designed RCTs is warranted to explore clinical efficacy.
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