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Published on: September 22, 2019
Nonsteroidal anti-inflammatory drugs and inflammatory bowel disease: pathophysiology and clinical associations
Ibrahim Habib1, Andrew Mazulis, Grigory Roginsky
1*Department of Medicine, Advocate Lutheran General Hospital, Park Ridge, Illinois; †Division of Gastroenterology, Department of Medicine, NorthShore University HealthSystem, Evanston, Illinois; and ‡Center for the Study of Complex Diseases, NorthShore University HealthSystem, Evanston, Illinois.
Abstract:
Nonsteroidal anti-inflammatory drugs (NSAIDs) produce significant gastrointestinal (GI) adverse events. Laboratory and clinical studies suggest that NSAIDs have the potential to trigger the onset or relapse of inflammatory bowel disease. In this review, the currently available information on the mechanism of action of NSAID injury of the GI tract and the pathophysiology of GI effects of NSAIDs, including immune dysregulation will be assessed. A detailed description of NSAID effects on individual GI organs will be discussed. This is followed by a MEDLINE review of clinical literature on the relationship between NSAID ingestion and the development and worsening of inflammatory bowel disease.
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