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Cytotoxic 5α,8α-epidioxy sterols from the marine sponge Monanchora sp

Bora Mun1, Weihong Wang, Hiyoung Kim

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Archives of Pharmacal Research
|September 19, 2014
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Cytotoxic edema is a form of cerebral edema characterized by intracellular swelling of neurons, astrocytes, and other glial cells. It develops when the mechanisms responsible for maintaining ionic gradients across the cell membrane become impaired. Under normal physiological conditions, the sodium–potassium ATPase actively transports sodium ions out of the cell and potassium ions into the cell, preserving osmotic balance and enabling electrical signaling. This pump requires a continuous...
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