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Recombinant bacillus Calmette-Guérin in urothelial bladder cancer immunotherapy: current strategies

Yonghua Wang1, Meng Yang, Qinchao Yu

  • 1Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, 266071, China.

Expert Review of Anticancer Therapy
|September 19, 2014
PubMed

Bacillus Calmette-Guérin (BCG) has been used in the intravesical treatment of urothelial bladder cancer (UBC) for three decades. Despite its efficacy, intravesical BCG therapy is associated with some limitations such as side effects and BCG failure, which have inspired multiple ways to improve it. Recent advances have focused on recombinant BCG (rBCG) which provides a novel tactic for modification of BCG. To date, a number of rBCG strains have been developed and demonstrated to encourage efficacy and safety in preclinical and clinical studies. This review summarizes current rBCG strategies, concerns and future directions in UBC immunotherapy with an intention to encourage further research and eventually to inform clinical decisions.

Keywords:
BCGbacillus Calmette-Guérinimmunotherapyintravesical therapyrecombinant BCGurothelial bladder cancer

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