Related Experiment Video

Updated: Apr 23, 2026

Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors
16:49

Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors

Published on: July 16, 2012

11.2K

Hepatitis C virus infection in the human immunodeficiency virus infected patient

Louise Nygaard Clausen1, Lene Fogt Lundbo1, Thomas Benfield1

  • 1Louise Nygaard Clausen, Lene Fogt Lundbo, Thomas Benfield, Department of Infectious Diseases, Hvidovre Hospital, University of Copenhagen, 2650 Hvidovre, Denmark.

World Journal of Gastroenterology
|September 19, 2014
PubMed

Insights

Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) coinfection is common, with liver disease now causing more deaths than AIDS. New direct-acting antiviral agents offer improved HCV cure rates for coinfected individuals.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Virology

Background:

  • Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) share transmission routes, leading to frequent coinfection, particularly in the Western world, affecting millions.
  • Injection drug use is the primary HCV transmission route, but sexual transmission among men who have sex with men is increasing.
  • Liver-related mortality now exceeds AIDS-related mortality in HIV-HCV coinfected individuals due to effective antiretroviral therapy.

Purpose of the Study:

  • To review the epidemiology, diagnosis, and natural history of HCV infection in HIV-HCV coinfected individuals.
  • To discuss current and future therapeutic strategies for HCV in the context of HIV coinfection.
  • To highlight the evolving landscape of HCV treatment and its impact on coinfected populations.

Main Methods:

  • Literature review focusing on epidemiology, diagnosis, natural history, and treatment of HCV in HIV-coinfected individuals.
  • Analysis of current direct-acting antiviral (DAA) therapies and their efficacy.
  • Exploration of future treatment paradigms and challenges.

Main Results:

  • HCV infection incidence peaked in the mid-1980s, with slow progression to cirrhosis in 15-20% of cases over 15-20 years.
  • Direct-acting antiviral agents have significantly improved HCV cure rates by targeting viral life cycle components.
  • Effective antiretroviral therapy for HIV has shifted mortality causes towards liver disease in coinfected patients.

Conclusions:

  • HIV-HCV coinfection presents a significant public health challenge, with increasing liver-related morbidity and mortality.
  • Current DAA therapies offer high cure rates for HCV, transforming treatment outcomes.
  • Future strategies must address sustained virologic response, potential drug resistance, and long-term liver disease management in coinfected individuals.

Keywords:
Hepatitis C virus epidemiologyHepatitis C virus treatmentHuman immunodeficiency virus - hepatitis C virus coinfectionNatural course of hepatitis C virus infection

More Related Videos

Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis10:12

Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis

Published on: September 11, 2019

7.9K
A Protocol for Analyzing Hepatitis C Virus Replication13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

23.7K

Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
74
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
89
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
1.8K
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion...
17
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
42.8K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
3.4K