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Surface micropattern limits bacterial contamination.

Ethan E Mann1, Dipankar Manna1, Michael R Mettetal1

  • 1Sharklet Technologies, Inc, 12635 E. Montview Blvd, Suite 160, Aurora, CO 80045, USA.

Antimicrobial Resistance and Infection Control
|September 19, 2014
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Summary

The Sharklet micropattern (MP) effectively reduces bacterial contamination on surfaces, outperforming antimicrobial copper in reducing Staphylococcus aureus (MSSA and MRSA) load. This non-toxic strategy shows promise for decreasing hospital-acquired infections.

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Area of Science:

  • Biomaterials Science
  • Infection Control
  • Microbiology

Background:

  • Bacterial surface contamination is a major factor in nosocomial infections.
  • Current chemical disinfectants pose toxicity risks and are prone to implementation errors.
  • Non-toxic surface strategies are needed to complement regular cleaning and reduce infection rates.

Purpose of the Study:

  • To evaluate the efficacy of the Sharklet micropattern (MP) in reducing colonization by methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA).
  • To compare the MP's performance against smooth control surfaces and antimicrobial copper under simulated clinical contamination conditions.

Main Methods:

  • Acrylic film surfaces with MP and smooth controls were inoculated via immersion, spray, and touch methods.
  • A combined touch transfer and drying (persistence) assay was developed to mimic clinical contamination scenarios.
  • The MP and antimicrobial copper were tested for their ability to reduce MSSA and MRSA contamination in this combined assay.

Main Results:

  • The MP demonstrated significant log reductions in bacterial contamination, ranging from 87-99% (LR 0.90-2.18) compared to smooth surfaces.
  • The MP outperformed antimicrobial copper (C11000), reducing MSSA by up to 97% (LR 1.54) and MRSA by up to 94% (LR 1.26).
  • Antimicrobial copper showed no significant effect on MSSA but reduced MRSA by 80% (LR 0.70).

Conclusions:

  • The developed assays effectively simulate hospital environmental contamination events.
  • The MP shows significant potential for reducing bacterial contamination under various conditions.
  • Further clinical studies are warranted to validate the MP's impact on reducing hospital-acquired infections (HAIs).