Related Experiment Video

Updated: Apr 23, 2026

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

2.6K

Subclinical cardiovascular disease in type 2 diabetes mellitus: To screen or not to screen

Juan J Chillarón1, Juana A Flores-Le Roux1, David Benaiges1

  • 1Juan J Chillarón, Juana A Flores-Le Roux, David Benaiges, Juan Pedro-Botet, Department of Endocrinology and Nutrition, Hospital del Mar, Passeig Marítim 25-29, 08003 Barcelona, Spain.

World Journal of Clinical Cases
|September 19, 2014
PubMed

Insights

Type 2 diabetes mellitus (T2DM) patients face high cardiovascular disease risk. Improved diagnostic tests are needed to better stratify risk and improve patient outcomes.

Area of Science:

  • Cardiology
  • Endocrinology
  • Public Health

Background:

  • Type 2 diabetes mellitus (T2DM) prevalence is increasing globally.
  • Cardiovascular disease (CVD) is the primary cause of mortality in T2DM patients.
  • Current risk factor management in T2DM often falls short of therapeutic goals in clinical practice.

Purpose of the Study:

  • To highlight the limitations of current diagnostic procedures for subclinical CVD in T2DM.
  • To emphasize the need for improved cardiovascular risk stratification in T2DM patients.
  • To suggest the development of more reliable, cost-effective diagnostic tests for subclinical atherosclerosis.

Main Methods:

  • Review of clinical trials and current clinical practice guidelines regarding CVD in T2DM.
  • Analysis of the prognostic value of existing diagnostic tests for subclinical CVD.
  • Identification of patient subgroups at high risk for CVD within the T2DM population.

Main Results:

  • Existing diagnostic tests for subclinical CVD in T2DM have not demonstrated improved prognosis or mortality.
  • Patients with extra-coronary atherosclerosis, microangiopathy, and uncontrolled risk factors are at elevated CVD risk.
  • Current guidelines do not systematically recommend screening for subclinical atherosclerosis in T2DM.

Conclusions:

  • There is a critical need for enhanced diagnostic tools to accurately stratify cardiovascular risk in T2DM.
  • Improved diagnostic test reliability, safety, and cost-efficiency are essential for clinical application.
  • Further research and evaluation are warranted to develop and validate new risk stratification strategies for T2DM patients.
Keywords:
Cardiovascular diseaseCardiovascular riskType 2 diabetes mellitus

More Related Videos

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

1.2K
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.6K

Related Concept Videos

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated...
9
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.8K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.5K
Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
8
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
8
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the...
14