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Cataract prevention in diabetic Octodon degus with Pfizer's sorbinil
1National Eye Institute, Bethesda, MD 20892.
Current Eye Research
|March 1, 1989
Abstract:
The Octodon degus has been reported to have higher aldose reductase activity in the lens compared to the gerbil and rat. When made diabetic the degus develop cataracts within 4 weeks. We have been able to completely prevent cataract formation in diabetic degus using Pfizer's sorbinil for up to 6 months. This is further evidence of the role of aldose reductase in the formation of cataracts in diabetes.