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Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
Published on: June 19, 2019
Seizures and brain regulatory systems: consciousness, sleep, and autonomic systems
Madineh Sedigh-Sarvestani1, Hal Blumenfeld, Tobias Loddenkemper
1*Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.; †Departments of Neurology, Neurobiology and Neurosurgery, Yale School of Medicine, New Haven, Connecticut, U.S.A.; ‡Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.; and §Department of Neurology, Columbia University, New York, New York, U.S.A.
Abstract:
Research into the physiologic underpinnings of epilepsy has revealed reciprocal relationships between seizures and the activity of several regulatory systems in the brain. This review highlights recent progress in understanding and using the relationships between seizures and the arousal or consciousness system, the sleep-wake and associated circadian system, and the central autonomic network.
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