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Related Concept Videos

Inhibition of Cdk Activity

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

Inhibition of CDK Activity

Inhibition of CDK Activity

Positive Regulator Molecules

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.

Positive Regulator Molecules

Positive Regulator Molecules

To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.

M-Cdk Drives Transition Into Mitosis

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...

M-Cdk Drives Transition Into Mitosis

M-Cdk Drives Transition Into Mitosis

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Related Experiment Video

Updated: Apr 23, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

Protein kinase C involvement in cell cycle modulation.

Alessandro Poli¹, Sara Mongiorgi¹, Lucio Cocco¹

¹*Cell Signaling Laboratory, Department of Biomedical Sciences (DIBINEM), University of Bologna, Italy.

Biochemical Society Transactions

|September 19, 2014

Summary

This summary is machine-generated.

Protein kinases C (PKCs) regulate cell cycle progression and differentiation by targeting key proteins like cyclins and lamins. Their precise role in cell proliferation varies, influencing checkpoints and cell cycle transitions.

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Last Updated: Apr 23, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

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Published on: May 3, 2018

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Monitoring Kinase and Phosphatase Activities Through the Cell Cycle by Ratiometric FRET

Monitoring Kinase and Phosphatase Activities Through the Cell Cycle by Ratiometric FRET

Published on: January 27, 2012

Area of Science:

Cell Biology
Molecular Biology
Biochemistry

Background:

Protein kinases C (PKCs) are crucial serine/threonine kinases involved in cellular regulation.
PKCs play multifaceted roles in cell cycle progression and differentiation, with effects dependent on context.
Their targets include key cell cycle regulators such as cyclins, cyclin-dependent kinases (Cdks), and lamins.

Purpose of the Study:

To review the regulatory roles of PKCs in cell proliferation and differentiation.
To highlight how PKCs affect key molecules involved in cell cycle progression.
To discuss the context-dependent nature of PKC involvement in cell cycle control.

Main Methods:

Literature review of studies on Protein Kinases C (PKCs).
Analysis of research on PKC involvement in cell cycle checkpoints (G₁/S and G₂/M).
Examination of PKC-mediated phosphorylation of cell cycle proteins and lamins.

Main Results:

PKCs can both promote and inhibit cell proliferation, impacting cell cycle entry, progression, and exit.
PKC activity influences G₁/S and G₂/M checkpoints, affecting cyclins and Cdks.
PKC isoenzymes can translocate to the nucleus and target lamins, leading to their disassembly during mitosis.

Conclusions:

PKCs are critical regulators of cell proliferation and differentiation.
The diverse roles of PKCs in the cell cycle underscore their importance in cellular processes.
Understanding PKC signaling pathways offers insights into cell cycle control and potential therapeutic targets.