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Updated: Apr 23, 2026
MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR
Published on: May 16, 2012
Detection of Xenotropic murine leukemia virus-related virus in prostate biopsy samples
Faraz Ahmed Baig1, Talat Mirza1, Rafiq Khanani2
1Departments of Histopathology, Dow Diagnostic Research and Reference Laboratory, Dow University of Health Sciences, Karachi.
Objective:
To determine the association of Xenotropic murine leukemia virus related virus (XMRV) infection with prostate cancer and compare it with benign prostate hyperplasia.
Study Design:
Case control study.
Place And Duration Of Study:
Department of Histopathology and Molecular Pathology, Dow University of Health Sciences, Karachi, from January 2009 to December 2012.
Methodology:
XMRV was screened in 50 prostate cancer and 50 benign prostatic hyperplasia biopsies using conventional end-point PCR. Other studied variables were family history of prostate cancer, patients age and Gleason score.
Results:
XMRV was detected in 4 (8%) of the 50 prostate cancer biopsy specimens compared to none in biopsies with benign prostatic hyperplasia. However, there was no significant statistical association of XMRV infection with the other variables.
Conclusion:
A low frequency of XMRV infection was found in this case-control study. Men, who harbor XMRV infection, may be at increased risk of prostate cancer but this needs to be investigated further at a larger scale.
